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A novel energy selection system to achieve FLASH dose-rates even for low-energy beams in cyclotron-based proton therapy facilities
(2022)In proton therapy, the potential of ultra-high (FLASH) dose-rate for cancer treatment is being explored due to its potential for enhancing biological effect, faster hypo-fractionated treatments and for efficient motion mitigation. However, energy degradation for FLASH irradiations using cyclotrons is far from optimal; if performed upstream (as common clinically, using a degrader plus an energy/momentum selection system, or ESS), very large ...Conference Poster -
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Intensity-modulated proton therapy treatment delivery of locally advanced non-small-cell lung cancers within a single breath-hold
(2021)Objective: We studied the feasibility of pencil beam scanning (PBS) proton therapy treatments within a single breath-hold at PSI’s Gantry 2. Treatment delivery time in PBS proton therapy depends on beam-on time and the dead time between proton spots (time required to change energy and/or lateral position). We studied ways to reduce beam-on and lateral scanning time, without sacrificing dosimetric plan quality, aiming at a single field ...Conference Poster -
Broadened Bragg Peak Shapes For Breath Hold Treatment: A Comparative Study
(2023)Conference Poster -
ITV or tumour tracking for dose painting of NSCLC? A comparison of target coverage and out-of-target dose in proton treatments
(2021)Introduction: Dose-escalation radiotherapy is used to calculate biologically adapted plan. When treating moving tumours the boost on the dose can be lost. We investigated the possibility to use tumour tracking for high precision dose painting in lung cancers. We chose a case where the target motion was below 5mm, normally recruited under free-breathing/rescanning-only protocol. We performed a comparative 4D dose calculation (4DDC) analysis ...Conference Poster -
Fast energy modulation within the beamline momentum acceptance: a clinical feasibility study
(2021)Conference Poster -
A novel intensity compensation method to achieve energy independent beam intensity at the patient location for cyclotron based proton therapy facilities
(2022)In cyclotron-based proton therapy facilities, an energy selection system is typically used to lower the beam energy from the fixed value provided by the accelerator (250/230 MeV) to the one needed for the treatment (230-70 MeV). Such a system has the drawback of increase beam emittance and introducing an energy-dependent beam current at the patient location, resulting in energy-dependent beam intensity ratios of about 10^3 between high ...Conference Poster -
A novel method of emittance matching to increase beam transmission for cyclotron-based proton therapy facilities
(2022)In proton therapy, high dose rates can reduce treatment delivery times, allowing for efficient mitigation of tumor motion and increased patient throughput. With cyclotrons however, high dose rates are difficult to achieve for low-energies as, typically, the emittance after the degrader is matched in both transversal planes using circular collimators, which does not provide an optimal matching to the acceptance of the following beamline. ...Conference Poster