On the influence of baseline startle reactivity on the indexation of prepulse inhibition
Abstract
Prepulse inhibition (PPI) of the startle reflex refers to the reduction of the reflexive startle response to an intense pulse stimulus when its presentation is shortly preceded by a weak prepulse stimulus. PPI is considered as a cross-species translational model of sensorimotor gating, and deficient PPI has been reported in a number of neuropsychiatric disorders. Although a part of the literature is based on the assumption that PPI is independent of the baseline startle reaction, there is accumulating evidence (Csomor et al., 2006; Sandner & Canal, 2007; Yee, Chang, Pietropaolo, & Feldon, 2005) that argues against such an independency. The authors systematically investigated whether PPI indexed as percentage or difference score is dependent on the magnitude of baseline startle reactivity in healthy human volunteers and in C57BL/6 mice. The results revealed that both indexations of PPI were affected by the magnitude of the baseline startle. The authors highlight the pitfalls of different methods to index PPI, especially when startle reactivity differs considerably between groups under comparison, and offer practical recommendations to satisfactorily deal with such baseline differences. (APA PsycInfo Database Record (c) 2016 APA, all rights reserved) Show more
Publication status
publishedExternal links
Journal / series
Behavioural NeuroscienceVolume
Pages / Article No.
Publisher
American Psychological AssociationSubject
prepulse inhibition; baseline startle; sensorimotor gating; human; miceOrganisational unit
03418 - Feldon, Joram
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