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A simple screen to identify promoters conferring high levels of phenotypic noise
(2008)PLoS GeneticsGenetically identical populations of unicellular organisms often show marked variation in some phenotypic traits. To investigate the molecular causes and possible biological functions of this phenotypic noise, it would be useful to have a method to identify genes whose expression varies stochastically on a certain time scale. Here, we developed such a method and used it for identifying genes with high levels of phenotypic noise in Salmonella ...Journal Article -
Spatial, environmental and anthropogenic effects on the taxon composition of hybridizing Daphnia
(2008)Philosophical Transactions of the Royal Society B: Biological SciencesThe competitive ability of hybrids, compared with their parental taxa, can cover a wide fitness range from poor to superior. For example communities of the Daphnia galeata–hyalina–cucullata species complex often show hybrid dominance. We tested whether taxa composition of 43 European lakes inhabited by this species complex can be explained by habitat characteristics (e.g. size descriptors, trophy level) or geography. We found that D. ...Journal Article -
Introduction. Extent, processes and evolutionary impact of interspecific hybridization in animals
(2008)Philosophical Transactions of the Royal Society B: Biological SciencesSince the time of Charles Darwin, studies of interspecific hybridization have been a major focus for evolutionary biologists. Although this phenomenon has often been viewed as problematic in the fields of ecology, taxonomy and systematics, it has become a primary source of data for studies on speciation and adaptation. Effects from genetic/evolutionary processes, such as recombination and natural selection, usually develop over extended ...Journal Article -
Heterotic AdS3/CFT2 duality with (0,4) spacetime supersymmetry
(2008)Nuclear Physics BJournal Article -
Rab1 Guanine Nucleotide Exchange Factor SidM Is a Major Phosphatidylinositol 4-Phosphate-binding Effector Protein of Legionella pneumophila
(2008)Journal of Biological ChemistryThe causative agent of Legionnaires disease, Legionella pneumophila, forms a replicative vacuole in phagocytes by means of the intracellular multiplication/defective organelle trafficking (Icm/Dot) type IV secretion system and translocated effector proteins, some of which subvert host GTP and phosphoinositide (PI) metabolism. The Icm/Dot substrate SidC anchors to the membrane of Legionella-containing vacuoles (LCVs) by specifically binding ...Journal Article