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Perfect crystals grown from imperfect interfaces
(2013)Scientific ReportsThe fabrication of advanced devices increasingly requires materials with different properties to be combined in the form of monolithic heterostructures. In practice this means growing epitaxial semiconductor layers on substrates often greatly differing in lattice parameters and thermal expansion coefficients. With increasing layer thickness the relaxation of misfit and thermal strains may cause dislocations, substrate bowing and even layer ...Journal Article -
Short communication: Development of an equation for estimating methane emissions of dairy cows from milk Fourier transform mid-infrared spectra by using reference data obtained exclusively from respiration chambers
(2018)Journal of Dairy ScienceEvaluation and mitigation of enteric methane (CH4) emissions from ruminant livestock, in particular from dairy cows, have acquired global importance for sustainable, climate-smart cattle production. Based on CH4 reference measurements obtained with the SF6 tracer technique to determine ruminal CH4 production, a current equation permits evaluation of individual daily CH4 emissions of dairy cows based on milk Fourier transform mid-infrared ...Journal Article -
Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivo
(2012)Nature CommunicationsEndothelial adherens junctions maintain vascular integrity. Arteries and veins differ in their permeability but whether organization and strength of their adherens junctions vary has not been demonstrated in vivo. Here we report that vascular endothelial cadherin, an endothelial specific adhesion protein located at adherens junctions, is phosphorylated in Y658 and Y685 in vivo in veins but not in arteries under resting conditions. This ...Journal Article -
Default Cascades in Complex Networks
(2013)Scientific ReportsThe recent crisis has brought to the fore a crucial question that remains still open: what would be the optimal architecture of financial systems? We investigate the stability of several benchmark topologies in a simple default cascading dynamics in bank networks. We analyze the interplay of several crucial drivers, i.e., network topology, banks' capital ratios, market illiquidity, and random vs targeted shocks. We find that, in general, ...Journal Article -
An intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acid
(2012)Nature CommunicationsWnt/β-catenin signalling controls development and tissue homeostasis. Moreover, activated β-catenin can be oncogenic and, notably, drives colorectal cancer. Inhibiting oncogenic β-catenin has proven a formidable challenge. Here we design a screen for small-molecule inhibitors of β-catenin's binding to its cofactor BCL9, and discover five related natural compounds, including carnosic acid from rosemary, which attenuates transcriptional ...Journal Article -
Size-dependent giant-magnetoresistance in millimeter scale GaAs/AlGaAs 2D electron devices
(2013)Scientific ReportsLarge changes in the electrical resistance induced by the application of a small magnetic field are potentially useful for device-applications. Such Giant Magneto-Resistance (GMR) effects also provide new insights into the physical phenomena involved in the associated electronic transport. This study examines a “bell-shape” negative GMR that grows in magnitude with decreasing temperatures in mm-wide devices fabricated from the high-mobility ...Journal Article -
New approach to detect seismic surface waves in 1Hz-sampled GPS time series
(2011)Scientific ReportsRecently, co-seismic seismic source characterization based on GPS measurements has been completed in near- and far-field with remarkable results. However, the accuracy of the ground displacement measurement inferred from GPS phase residuals is still depending of the distribution of satellites in the sky. We test here a method, based on the double difference (DD) computations of Line of Sight (LOS), that allows detecting 3D co-seismic ...Journal Article -
Automated Feedback Selection for Robot-Assisted Training
(2017)International Journal of Computer Science in SportRobot-assisted training can be enhanced by using augmented feedback to support trainees during learning. Efficacy of augmented feedback is assumed to be dependent on the trainee's skill level and task characteristics. Thus, selecting the most efficient augmented feedback for individual subjects over the course of training is challenging.We present a general concept to automate feedback selection based on predicted performance improvement. ...Journal Article -
Development of a new real-time quantitative PCR assay for the detection of Staphylococcus aureus genotype B in cow milk, targeting the new gene adlb
(2017)Journal of Dairy ScienceThe specific and reliable diagnosis of mastitis pathogens is essential for successful sanitation programs. The aim of the present study was to develop and evaluate a new real-time quantitative PCR (qPCR) assay for the very sensitive and specific detection of Staphylococcus aureus genotype B in cow milk samples. This mastitis pathogen is contagious and particularly prevalent in Switzerland and other central European countries. The new test ...Journal Article -
Heterogeneous terahertz quantum cascade lasers exceeding 1.9 THz spectral bandwidth and featuring dual comb operation
(2018)NanophotonicsWe report on a heterogeneous active region design for terahertz quantum cascade laser based frequency combs. Dynamic range, spectral bandwidth and output power have been significantly improved with respect to previous designs. When individually operating the lasers, narrow and stable intermode beatnote indicate frequency comb operation up to a spectral bandwidth of 1.1 THz, while in a dispersion-dominated regime a bandwidth up to 1.94 THz ...Journal Article