A gene-targeted polymerase-mediated strategy to identify O6 -methylguanine damage
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Open access
Date
2019-04-07Type
- Journal Article
Abstract
Detecting DNA adducts in cancer genes is important for understanding cancer etiology. This study reports a strategy to identify the mutagenic DNA adduct O6-methylguanine in K-Ras. The strategy involves selective replication past a synthetic primer when placed opposite O6-methylguanine. Future work can apply this approach to other cancer-relevant genes. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000338778Publication status
publishedExternal links
Journal / series
Chemical CommunicationsVolume
Pages / Article No.
Publisher
Royal Society of ChemistryOrganisational unit
03853 - Sturla, Shana / Sturla, Shana
Funding
156280 - DNA Alkylation and Resistance in Antitumor Drug Toxicity (SNF)
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