- Doctoral Thesis
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It is Zeu’s anathema on Magnetic Resonance Imaging (MRI) of the lung that we should agonize between the Scylla of the rapid decaying magnetization signal and the Harybdis of respiratory motion and long acquisition times. This thesis deals with the clinical issues of the aforementioned problems. The main core of the work is to optimize the 3D Ultrashort echo-time (UTE) Cones sequence for lung imaging in terms of image quality, respiratiory motion and acquisition times, primarily for visualization and quantification of the lung parenchyma. Especially for the lung, the conventional MRI sequences cannot capture signal from the parenchyma and in general the images are not of sufficient diagnostic value. 3D UTE Cones, is tested clinically on pediatric patients referred for lung lesions and compared to the routine sequence -Periodically Rotated Overlapping Parallel Lines with Enhanced Reconstruction (PROPELLER). Cones is able to capture the lung density based on the patient’s age and additionally sets itself as a proper sequence for lung Positron Emission Tomography (PET) attenuation correction (AC) in PET/MR scans. Another two chapters regard retrospective gating of the lung motion based on the extracted DC self-navigator from the central k-space and description of the development of conjugate gradient (CG)-SENSE reconstruction for the non-cartesion Cones parallel imaging using sensitivity maps generated by the image data for fast MR lung imaging. Supplementary, one publication regards the clinical comparison of the image quality between time-of-flight (TOF)-PET/CT and TOF-PET/MRI in relation to various acquisition times proving the superior PET sensitivity of the PET/MRI. Mehr anzeigen
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ThemaMRI (magnetic resonance imaging); MRI; Medical imaging; Lung; LUNG DIAGNOSTICS (MEDICINE); Ultrashort echo-time MRI; Zero echo time
Organisationseinheit03628 - Prüssmann, Klaas P. / Prüssmann, Klaas P.